Synedgen Appoints Industry Veteran Dennis Fenton, Ph.D., to Board of Directors

CLAREMONT, Calif. February 18, 2021 – Synedgen, a biopharma company dedicated to using its Multivalent Innate Immune Signaling Target (MIIST) platform to develop drugs that mimic and enhance the innate immune system, today announced that industry veteran Dennis Fenton, Ph.D., has joined Synedgen’s Board of Directors. Dr. Fenton is a prominent figure in the biotechnology industry and brings more than 30 years of experience in various roles such as operations, manufacturing and partnering.

“We are quite pleased that Dennis has chosen to join Synedgen’s board, given his breadth of experience and relationships in the biotech community and his leadership in successful drug development,” said Shenda Baker, CEO and President of Synedgen. “On behalf of Synedgen’s management and Board, I welcome Dennis and look forward to benefiting from his strategic, operational and clinical knowledge in the years to come.”

“I am excited to be joining Synedgen just as the company contemplates a number of key strategic and development decisions,” said Dr. Dennis Fenton. “During my thirty-plus-year career in biotechnology, I’ve had the opportunity to work with both big and small pharma, and I am particularly impressed by Synedgen’s MIIST platform and the multiple disease areas in which it has been and could be deployed.”

Dennis Fenton, Ph.D., is a member of the board of directors for AnaptysBio, Cirius Therapeutics and Modern Meadow. Previously, Dr. Fenton served on the board of directors of Hospira, Portola Pharmaceuticals, Dendreon, Genzyme, Kythera Biopharmaceuticals, XenoPort, Nora Therapeutics and Amira Pharmaceuticals. Dr. Fenton began his career at Pfizer as a senior researcher before joining Amgen in their first years of operations. Dr. Fenton worked at Amgen for 25 years and held several notable roles, including Executive Vice President, Operations at his retirement in 2008. Dr. Fenton received his Ph.D. in microbiology from Rutgers University.

About Synedgen

Synedgen Inc. is a privately held biopharma company that has developed a first-in-class Multivalent Innate Immune Signaling Target (MIIST) therapeutic platform. MIIST therapeutics target mucosal signaling in response to damage to control inflammation, regeneration and infection. Successes from this platform include SNSP113, a Phase 2 drug for Cystic Fibrosis out-licensed to Synspira Therapeutics, Inc. Synedgen’s internal lead asset is MIIST305, a clinic-ready, oral, immunomodulatory drug candidate that repairs GI injury by directing innate mucosal responses to restore GI function and reduce unchecked inflammation and damage. Synedgen is currently developing MIIST305 for the treatment of GI mucositis, a well-defined, acute injury, inflicted on the gastrointestinal tract by radiation and chemotherapeutics during cancer treatment. For more information, please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com

Synedgen Partnership with the University of New South Wales Receives Australian Research Council (ARC) Grant

– Grant will fund understanding of the biochemical and biophysical structure of the endothelial glycocalyx –

– Synedgen’s CEO, Shenda Baker, gave a related keynote lecture at the Pan Pacific Connective Tissue Societies Symposium on November 25, 2020 –

 

CLAREMONT, Calif., December 10, 2020 – Synedgen, a biotechnology company using glycopolymer chemistry to develop drugs that enhance and control signaling in the innate immune system, today announced that UNSW in partnership with Synedgen has been awarded an A$600,633, 3-year, research grant from the Australian Research Council (ARC) to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx. The resulting study will be the first to explore how charged glycopolymers interact with the endothelial glycocalyx with the goal of mapping the lifecycle of the network of membrane-bound proteoglycans and glycoprotein.

“Synedgen is developing molecules that interact with the glycocalyx to control the movement of cells and molecules across the endothelium and we are keen to deepen the understanding of the dynamic structure of, and implicit role of, the endothelial glycocalyx in innate immune signaling. This ARC-funded project aims to address this knowledge deficit by mechanistically elucidating and describing the dynamic lifecycle of the endothelial glycocalyx,” said Shenda Baker, Ph.D., President and Chief Executive Officer of Synedgen. “We are grateful to the ARC for this grant and honored to be working with Drs. Megan Lord and John Whitelock of the University of New South Wales, experts in proteoglycan interactions and signaling. We anticipate that results of these efforts can be leveraged to inform the development of targeted molecules to treat diseases involving the endothelial glycocalyx including cardiovascular and pulmonary diseases, stroke and traumatic brain injury.”

“We still have much to learn about the structure and dynamics of the endothelial glycocalyx, a network of proteoglycans and glycosaminoglycans anchored at the cell surface,” said Megan Lord, Ph.D., lead PI on the grant. “Synedgen’s glycopolymers will enable us to study interactions at the endothelial interface and develop new ways to support endothelial functions.”

Synedgen believes the findings of the ARC-sponsored project will inform the company’s future research and development activities over the next 3-7 years.

Synedgen’s CEO, Shenda Baker, gave a related keynote lecture at the Pan Pacific Connective Tissue Societies Symposium on November 25, 2020, titled, “Glycopolymer interactions with the glycocalyx to modulate innate immune responses after dermal injury.” The 12th Pan Pacific Connective Tissue Societies Symposium, a virtual event held in November 2020, was held in conjunction with the scientific meetings of the Australian Wound & Tissue Repair Society (AWTRS) and Matrix Biology Society of Australia and New Zealand (MBSANZ).

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The company’s lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgen’s glycopolymer platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com

Synedgen Receives Supplemental NEI Funding To Identify Lead Development Candidate for Ocular Mustard Gas Injury Program

– Additional funding increases cumulative NEI commitment to over $1 million –

– All selected molecules synthesized under this initiative have met prerequisite development criteria –

 

CLAREMONT, Calif. October 29, 2020 – Synedgen, a biotechnology company using glycopolymer chemistry to develop drugs that enhance and control signaling in the innate immune system, today announced supplemental funding from the National Eye Institute (NEI) of the NIH to identify a lead molecule from the company’s ocular mustard gas injury program to move into animal studies.

Synedgen has developed a new class of glycopolymers with the ability to suppress inflammation, reduce infection, and improve healing at mucosal surfaces. To date, Synedgen has utilized NEI-funding to synthesize and test a suite of new molecules, using the company’s proprietary glycopolymer platform, with the potential to treat the acute and chronic effects of ocular chemical toxicity. Synedgen today announced that all of the selected molecules under this effort have met the prerequisite criteria for cell surface association, cellular regeneration and anti-inflammatory activity to move forward into the next phase of testing. The additional funding from the NEI provides resources to optimize down-selection to a lead molecule to advance into animal studies.

“We are thankful for the NEI’s continued support of our ocular mustard gas injury program, which has added a number of active novel glycopolymers to our library,” said Shenda Baker, Ph.D., President and Chief Executive Officer of Synedgen. “By targeting the unique environment of the corneal surface, we have created a new suite of molecules with the potential to target an expanded range of ocular indications. These molecules have good residence time in the eye, and provide a unique barrier function that is similar to the eyes’ natural tear layer.  In addition, they are designed to encourage healing, reduce inflammation and significantly decrease corneal fibrosis, which is a proxy for vision loss.”

Synedgen’s ocular mustard gas injury program supports development of a potential treatment for military and civilian ocular injuries caused by sulfur mustard (SM). SM is employed as a chemical weapon, and its increasing production and use in unstable regions throughout the world heightens the risk that it could one day be used in a terrorist attack against U.S. civilians or armed forces, potentially causing severe burns to the eyes, skin and respiratory tract. The ocular surface is uniquely susceptible to SM, resulting in corneal lesions, edema, ulceration, neovascularization and vision loss. There are currently no FDA-approved drugs for SM-induced ocular injuries to improve healing and reduce vision loss.

The supplemental funding announced today facilitates the assessment of the optimized molecules in an ocular tissue model consisting of normal human corneal epithelial cells cultured to form a stratified, squamous epithelium which closely parallels normal human corneal tissue. The corneal cells differentiate to form a multi-layered structure with metabolically active tissue having barrier properties similar to the human cornea and are used to predict activity in the human cornea. Using this data, Synedgen plans to select a lead development candidate to progress into animal trials.

About The Award

Research reported was supported by the National Eye Institute (NEI/NIH) and the NIH Office of the Director (OD) under Award Number U01EY030406. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The company’s lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgen’s glycopolymer platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com

Synedgen Announces $1 Million Award from Defense Health Agency to Develop SynePure and Catasyn

– Funds commercialization and head-to-head clinical trial against current standard of care –

– Also announces abstract at 9th RAND Corporation and Department of Defense State-of-the-Science Meeting on Blast-Related Burn Injury Research –

CLAREMONT, Calif. March 3, 2020 – Synedgen, a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system, today announced a combined $1 million award from the Defense Health Agency (DHA) Small Business Innovation Research Program (SBIR), along with additional research funds from the DHA, to commercialize its products, SynePure™ Wound Cleanser (SynePure) and Catasyn™ Advanced Technology Wound Hydrogel (Catasyn), developed under DHA SBIR award W81XWH-16-C-0023, and to perform a randomized clinical trial comparing them to the current standard of care in patients with partial thickness (2nd degree) burns. Synedgen has chosen the University of Pittsburgh Medical Center (UPMC) Mercy Trauma and Burn Center as its subcontractor for the clinical program.

“Bringing these products to patients is the realization of Synedgen’s commitment to finding solutions for intractable and unmet needs in infection, inflammation and healing,” said William Wiesmann, MD, Executive Chairman of Synedgen’s Board. “Both military and civilian burns are typically chronically infected and inflamed, often leading to disfiguring scars. This funding allows us to quickly advance our products into patients, where we anticipate increased healing rates with reduced fibrosis, even in wounds with multi-drug resistant bacteria. We would like to formally thank our sponsors at the DHA for their assistance to date.”

 

Development of SynePure and Catasyn has been funded by the DHA as well as the Defense Advanced Research Projects Agency (DARPA) SBIR Program. Both products are Food and Drug Administration (FDA) 510(k) cleared medical devices formulated with glycopolymers from Synedgen’s platform.

 

Additionally, Synedgen today announced a presentation to be given at the 9th Department of Defense State-of-the-Science Meeting on Blast Injury Research. The meeting is co-sponsored by  the RAND Corporation and the Department of Defense (DoD) Blast Injury Research Coordinating Office (BIRCO) and titled “Mitigating the Impact of Blast-related Burn Injuries: From Prolonged Field Care to Rehabilitation and Resilience”, will take place in Arlington, Virginia, on March 3-5, 2020.

 

Kaveri Parker, Ph.D., Synedgen’s Chief Business Officer, will give an oral presentation detailing the company’s solutions for polytraumatic combat injuries resulting from explosive device detonation, the management of which poses unique patient- and field-management challenges. Synedgen has developed SynePure and Catasyn to provide a burn injury treatment portfolio capable of managing these care considerations. SynePure has been optimized for the cleansing of wounds and thermal injuries, while Catasyn serves as a protective gel dressing.

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The company’s lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgen’s glycochemistry platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com

Synedgen To Present Data on Therapeutic for Ocular Mustard Gas Injury at NIH-Organized Medical Countermeasures Meeting

– First results from ocular injury program to treat damage from sulfur mustard gas –

– Announces $1 million funding from the National Eye Institute for continuation of program development –

CLAREMONT, Calif. February 18, 2020 – Synedgen, a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system, today announced a poster presentation at the upcoming National Institutes of Health  (NIH)-organized scientific meeting, “Developing Medical Countermeasures To Treat the Acute and Chronic Effects of Ocular Chemical Toxicity”. The meeting will take place in Rockville, Maryland, on February 25-26, 2020.

Poster Presentation:

Title: Improving Corneal Wound Healing After Chemical Injury With Novel Therapeutic Glycopolymers

Presenter: Shenda Baker, Ph.D.

Date: Tuesday, February 25, 2020

Time: 2:00 p.m. – 3:00 p.m. ET

Location: National Institute of Allergy and Infectious Diseases (NIAID/NIH) Conference Center, 5601 Fishers Lane, Rockville, Maryland 20852

“We’re excited to share this promising data from Synedgen’s ophthalmic glycopolymer candidates, given the lack of effective drugs for this type of damage to the eye,” said Dr. Brian Gilger, study lead and Professor of Ophthalmology at North Carolina State University College of Veterinary Medicine. “Importantly, the new molecules from Synedgen’s glycopolymer platform have the potential not only to provide a powerful countermeasures solution, but also to be applied in the civilian market where corneal damage is a frequent cause of vision loss.”

Sulfur Mustard (SM) is employed as a chemical weapon, and its increasing production and use in unstable regions throughout the world heightens the risk that it could be used in a terrorist attack against U.S. civilians or armed forces, potentially causing severe burns to the eyes, skin and respiratory tract. The ocular surface is uniquely susceptible to SM, resulting in corneal lesions, edema, ulceration, neovascularization and vision loss. There are currently no FDA-approved drugs for SM-induced ocular injuries to improve healing and reduce vision loss.

Synedgen has developed a class of glycopolymers with the ability to suppress inflammation, reduce infection, and improve healing at mucosal surfaces. One such glycopolymer reduces epithelial damage and inflammation in an animal model of potassium hydroxide (KOH)-induced ocular injury. This glycopolymer was well-tolerated, with reduced initial ocular inflammation (measured by Hackett-McDonald ocular scores) at 12 hours, and lower subsequent cumulative ocular inflammation. Furthermore, relative to control, the treatment prevented significant secondary ulceration, improved the healing rate and reduced corneal fibrosis. Given these results, preliminary optimization of five related compounds has been initiated in order to optimize the therapeutic efficacy of lead molecules against SM burns. This program is being funded by a three-year $970,000 award from the National Eye Institute (NEI/NIH) and the NIH Office of the Director (OD). The award is specifically earmarked for the “Identification of lead compounds to topically treat sulfur mustard injury to reduce ocular damage and improve vision.”

About Award

Research reported was supported by the National Eye Institute (NEI/NIH) and the NIH Office of the Director (OD) under Award Number U01EY030406. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The company’s lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgen’s glycochemistry platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com

Synedgen Receives $2.6 Million in Private Financing For Wound Care Portfolio

– Investment funds commercialization efforts for FDA 510(k)-cleared products Catasyn and SynePure –

CLAREMONT, Calif. January 29, 2020 – Synedgen, a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system, today announced that it has received $2.6 million in private financing to fund the commercialization of Catasyn™ Advanced Technology Wound Hydrogel and SynePure™ Wound Cleanser, two U. S. Food and Drug Administration (FDA) 510(k)-cleared products that form part of Synedgen’s Wound Care portfolio.

The development of Catasyn and SynePure, which address complex wounds, has been supported respectively by U.S. Army (W81XWH-16-C-0023) and Defense Advanced Research Projects Agency (DARPA, N66001-14-C-4009) grants. Clinical trials are planned for both products in anticipation of increasing their technological readiness level (TRL) for broad DoD adoption.

“I’m delighted to announce that we have secured financing to launch our two Wound Care products, Catasyn and SynePure, two innovative treatments borne out of Synedgen’s glycochemistry technology platform. This focused investment will fund commercialization and final manufacturing processes, as well as future indication expansion efforts for these wound care products,” said Shenda Baker, Ph.D., CEO and President of Synedgen. “Synedgen has developed its Wound Care portfolio to provide superior wound cleansing and wound management without contributing to antimicrobial resistance. The company’s Wound Care products support a healthy environment for healing, without harsh chemicals that can further inflame and delay healing of already damaged tissue. I’m pleased that today’s investment will help put these much-needed treatments into the hands of patients.”

In its OTC indication, Catasyn can be used for the dressing and management of minor burns, minor cuts, minor lacerations, minor abrasions, and minor irritations of the skin. When administered by a healthcare professional, Catasyn can be used for the dressing and management of partial to full thickness dermal ulcers including pressure sores, venous stasis ulcers, arterial ulcers and diabetic ulcers, surgical wounds including post-operative incisions and donor sites, and superficial and partial thickness (second degree) burns.

SynePure is specifically designed to provide immediate and effective irrigation of wounds following injury and is designed to become part of the first aid kit carried by all U.S. soldiers. It is packaged for use in a squeezable bottle fitted with a nozzle to direct a focused stream of cleanser with sufficient force to help dislodge debris and contamination. SynePure’s advanced glycopolymer technology aggregates contaminants in the wound to help facilitate their removal. SynePure is also suitable for hospital and emergency care use, with clearance for both single- and multiple-use bottles.

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The company’s lead development candidate is SYGN305, for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgen’s glycochemistry platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com

 

 

 

 

Synedgen Granted New EU Patent For Treating GI Mucositis

– Patent adds to company’s robust portfolio covering lead development candidate SYGN305 –

CLAREMONT, Calif. January 15, 2020 – Synedgen, a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system, today announced the award of a new patent by the European Patent Office (EPO), covering aspects of the treatment of mucositis in the gastrointestinal (GI) tract with Synedgen’s glycopolymer platform of molecules (EP 2555760).

The new patent extends the geographic coverage of Synedgen’s IP estate, with the company having already been granted similar patents in the United States (US 9,439,925), Australia, Canada and Japan. The new patent award adds to Synedgen’s robust portfolio covering the treatment of GI mucositis, and its lead product candidate SYGN305, as well as to its overall body of patents and patent applications, which now total more than 45 worldwide, reflecting the breadth and depth of the company’s glycochemistry expertise, and its ongoing and expanding application to new disease areas.

“This new patent strengthens the coverage of our intellectual property for our lead candidate, SYGN305, in development for the treatment of GI mucositis, a key dose-limiting factor for cancer therapies,” said Shenda Baker, Ph.D., CEO and President of Synedgen. “In preclinical testing, SYGN305 has been shown to reduce inflammation and tissue damage in animal models of radiation injury. We believe this program has the potential to help alleviate chronic intestinal dysfunction during cancer treatments, allowing for greater treatment compliance and potentially increasing dose tolerance. Importantly, SYGN305 is derived from the same platform technology as our existing U.S.-marketed products, giving us a high degree of confidence in the product candidate’s potential safety and efficacy.”

About Gastrointestinal Mucositis

Gastrointestinal mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually resulting from an adverse effect of chemotherapy and radiotherapy treatment for cancer. GI mucositis causes serious pathologies along the alimentary tract, often resulting in intolerance to cancer treatments, reduced treatment adherence and damage to the quality of life of the oncologic patient. The damage can be life-threatening or result in chronic GI complications. No currently approved therapies to treat GI mucositis are available to patients.

 

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The company’s lead development candidate is SYGN305, for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgen’s glycochemistry platform has already generated five FDA 510(k) cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com

Synedgen Awarded Funding to Advance Inflammatory Bowel Disease Treatments

– Glycopolymers aimed at reducing inflammation and damage associated with ulcerations of the lower bowel –

CLAREMONT, Calif. December 13, 2019 – Synedgen, a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system, today announced the award of a competitive Congressionally Directed Medical Research Program (CDMRP) contract. Administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA), this award enables Synedgen to optimize therapeutic treatments that restore innate gastrointestinal (GI) integrity damaged by inflammatory bowel diseases (IBD).

Synedgen plans to use the $259k grant to complete preclinical efficacy studies for several formulations of its proprietary glycopolymer pharmaceuticals to reduce GI inflammation, leaky bowl syndrome, and ulcerative damage in a model of ulcerative colitis (UC).

“This award enables Synedgen to further expand its growing portfolio of glycopolymer therapeutics designed to treat damage to, and inflammatory conditions of, mucosal surfaces like the GI tract,” said Shenda Baker, CEO and President of Synedgen. “Our surface-active glycopolymers have broad mechanisms of action and have been shown to reduce inflammation and tissue damage in animal models of IBD and radiation injury. The studies planned under this award are designed to optimize the drug molecular structure and dosing prior to clinical development. We would like to formally express our gratitude to USAMRAA for this grant.”

Synedgen has developed several derivatives of its proprietary high molecular weight glycol-polymer therapeutics that reduce inflammation, improve healing and restore integrity along the length of the GI tract. Synedgen’s orally delivered GI treatments have demonstrated a robust ability to reduce local and systemic inflammation, lessen cell death, and improve tissue regeneration associated with chemical, physical and radiation-induced damage in the large and small intestines in animal models that mimic conditions seen in human UC and Crohn’s disease.

About IBD

IBD generally describes disorders that involve chronic inflammation of the digestive tract. Types of IBD include UC, which causes long-lasting inflammation and sores (ulcers) in the innermost lining of the large intestine and rectum, and Crohn’s disease, which is characterized by chronic inflammation of the lining of the digestive tract. Both UC and Crohn’s disease usually involve severe diarrhea, abdominal pain, fatigue and weight loss. Although they are separate conditions, they share common features of intestinal inflammation and ulceration and significant reduction in quality of life for IBD patients. In a healthy gut, the GI microenvironment can auto-regulate and maintain a stable state with the normal bacterial flora and support an intact gut barrier. The intestine normally controls permeability, allowing nutrients to pass through while also maintaining a barrier function to keep potentially harmful substances and bacteria from migrating more widely into the body. In a damaged or inflamed gut, such as in patients with IBD, dysfunction of the mucosal barrier allows penetration of both “good” and “bad” microbes onto and through the intestinal cell wall and into circulation which can lead to severe systemic complications.

About the Award

The U.S. Army Medical Research Acquisition Activity, 839 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. This work was supported by the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program under Award No. W81XWH-19-1-0165. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. In conducting research using animals, the investigators adhere to the laws of the United States and regulations of the Department of Agriculture.

 

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The company’s lead development candidate is SYGN305, for GI Mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer therapy. Synedgen’s glycochemistry platform has already generated five FDA 510(k) cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit www.synedgen.com.

 

Contact:

Laurence Watts

Gilmartin Group, LLC.

619 916 7620

laurence@gilmartinir.com